Ethyl 3-(2-chloro-5,6-dimethyl-3-pyridyl)acrylate → Ethyl 3-(5,6-dimethyl-3-pyridyl)propionate

HRID 224868노트

반응식

HRID 224868 반응식
Cl[C:2]1[C:7]([CH:8]=[CH:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][C:5]([CH3:15])=[C:4]([CH3:16])[N:3]=1>C(O)C.[Pd]>[CH3:15][C:5]1[CH:6]=[C:7]([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:2]=[N:3][C:4]=1[CH3:16]

참가 물질

4

반응물 1

HCID 53884840Ethyl 3-(2-chloro-5,6-dimethyl-3-pyridyl)acrylate

생성물 1

HCID 14576944Ethyl 3-(5,6-dimethyl-3-pyridyl)propionate수율 80%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Ethyl 3-(2-chloro-5,6-dimethyl-3-pyridyl)acrylate (32.7 gZ) in ethanol (500 ml) was hydrogenated at 25°-30° and 344 kPa using palladium-on-charcoal catalyst (5%, 3 g). The mixture was filtered and the filtrate was evaporated to an oil which was partitioned between chloroform and 2 N hydrochloric acid. The aqueous phase was made basic with aqueous sodium hyroxide, extracted with chloroform and the chloroform extracts were evaporated to give ethyl 3-(5,6-dimethyl-3-pyridyl)propionate (21.8 g, 80%) as an oil.

후처리

  1. customwas hydrogenated at 25°-30°
  2. filtrationThe mixture was filtered
  3. customthe filtrate was evaporated to an oil which
  4. customwas partitioned between chloroform and 2 N hydrochloric acid
  5. extractionextracted with chloroform
  6. customthe chloroform extracts were evaporated

출처 및 근거

ORD 기록
ord-031b94fa27f84dce9de294f6ee626aaf
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04234588

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