Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cystamine → 2-[5-(3-Pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cystamine | HCID 2915 | — |
| 반응물 | 5-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-one | HCID 3018360 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-[5-(3-Pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide | HCID 53790692 | — |
반응 단계
Cystamine is reacted with 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone by heating in ethanol to give 2-[5-(3-pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide which is reduced with dithiothreitol to give 2-(2-mercaptoethylamino)-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone which is reacted with 5-dimethylaminomethyl-2-furylmethanol in cold aqueous hydrochloric acid to give 2-[2-(5-dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04234588 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-dd39f81c0d1049d6b4e85554e4e11c6c |
| 출처 메모 | uspto-grants-1980_11 |