Ethanol → 2-(Acetoxyacetylamino)-6-aminobenzamide

HRID 2248763노트

반응식

HRID 2248763 반응식
[C:1]([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-])=O)[C:10]=1[C:11]#[N:12])=[O:7])(=[O:3])[CH3:2].C1CCCCC=1.C([OH:28])C>[C].[Pd]>[C:1]([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([NH2:17])[C:10]=1[C:11]([NH2:12])=[O:28])=[O:7])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 702EthanolHCID 8079CyclohexeneHCID 149862822-(Acetoxyacetylamino)-6-nitrobenzonitrile

생성물 1

HCID 149862792-(Acetoxyacetylamino)-6-aminobenzamide

시약·촉매·용매 1

HCID 178418390HCID 178418390, 화합물촉매

실험 절차

To a mixture of 2-(acetoxyacetylamino)-6-nitrobenzonitrile (5.7 g) and ethanol (50 ml) are added cyclohexene (10.5 ml) and 10% palladium-carbon (4.7 g). The mixture is refluxed for 20 minutes, and the reaction mixture is cooled to room temperature, and the solid materials are filtered off. The filtrate is distilled under reduced pressure. The residual crude crystals are recrystallized from ethanol to give the title compound (1.2 g) having the following physical properties.

후처리

  1. temperatureThe mixture is refluxed for 20 minutes
  2. filtrationthe solid materials are filtered off
  3. distillationThe filtrate is distilled under reduced pressure
  4. customThe residual crude crystals are recrystallized from ethanol

출처 및 근거

ORD 기록
ord-3ea07f62c85c475d8ad9dfedc7d035e2
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05041462

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