1-Propanol → n-Propyl-5-hydroxybenzoxazole-2-carboxylate

HRID 2248882노트

반응식

HRID 2248882 반응식
[C:1]([C:4]1[O:5][C:6]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:7]=2[N:8]=1)([OH:3])=[O:2].[CH2:14](O)[CH2:15][CH3:16]>S(=O)(=O)(O)O>[CH2:14]([O:2][C:1]([C:4]1[O:5][C:6]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:7]=2[N:8]=1)=[O:3])[CH2:15][CH3:16]

참가 물질

4

반응물 2

HCID 10311-PropanolHCID 199946752-Carboxy-5-hydroxybenzoxazole

생성물 1

HCID 86745010n-Propyl-5-hydroxybenzoxazole-2-carboxylate

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

실험 절차

12.72 g (49.2 mmoles) of 2-carboxy-5-hydroxybenzoxazole is dissolved in 200 ml of n-propanol and 1 drop of concentrated sulfuric acid is added. The mixture is refluxed for 30 hours, concentrated. The resulting solid is suspended in water, neutralized with sodium bicarbonate and filtered, washing the solid with water, then drying. This gives n-propyl-5-hydroxybenzoxazole-2carboxylate which is purified by recrystallization from n-propanol/acetone or by HPLC.

후처리

  1. temperatureThe mixture is refluxed for 30 hours
  2. concentrationconcentrated
  3. filtrationfiltered
  4. washwashing the solid with water
  5. customdrying
  6. customThis gives n-propyl-5-hydroxybenzoxazole-2carboxylate which is purified by recrystallization from n-propanol/acetone or by HPLC

출처 및 근거

ORD 기록
ord-d0d085ee63aa4284af57944cf079e191
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05041453

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