Acetyl chloride → N-[(1S,2S)-2-Hydroxycyclopentyl]acetamide

HRID 2249206노트

반응식

HRID 2249206 반응식
[NH2:1][C@H:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[OH:7].[C:8](Cl)(=[O:10])[CH3:9]>>[OH:7][C@H:3]1[CH2:4][CH2:5][CH2:6][C@@H:2]1[NH:1][C:8](=[O:10])[CH3:9]

참가 물질

3

반응물 2

HCID 6367Acetyl chlorideHCID 11571787(1S,2S)-2-Aminocyclopentanol

생성물 1

HCID 14988810N-[(1S,2S)-2-Hydroxycyclopentyl]acetamide

실험 절차

Following the procedure of Example 2A, 74.7 g of (S,S)-(+)-2-aminocyclopentanol were reacted with acetyl chloride to provide 107.9 g of the title intermediate as an oil which crystallized upon cooling. NMR.

출처 및 근거

ORD 기록
ord-5a457c89e5e443ada306c9b1088ca9ef
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05043341

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