Sulfuric Acid → HCID 19825785, 화합물

HRID 2249210노트

반응식

HRID 2249210 반응식
S(=O)(=O)(O)O.O[C:7]([CH:10]1[CH2:14][C:13]2[CH:15]=[C:16]([OH:21])[C:17]([O:19][CH3:20])=[CH:18][C:12]=2[O:11]1)([CH3:9])[CH3:8]>>[OH:21][C:16]1[C:17]([O:19][CH3:20])=[CH:18][C:12]2[O:11][C:10]([CH:7]([CH3:9])[CH3:8])=[CH:14][C:13]=2[CH:15]=1

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 19825784HCID 19825784, 화합물

생성물 1

HCID 19825785HCID 19825785, 화합물수율 43.5%

실험 절차

To a solution of conc. sulfuric acid (1 ml) was added 2,3-dihydro-2-(1-hydroxy-1-methylethyl)-6-methoxy-5-benzofuranol (50 mg) in several portions during a period of few minutes. The mixture was stirred for 10 minutes at ambient temperature and poured into ice water. The separated oil was extracted with methylene chloride. The organic layer was washed with water, dried, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (n-hexane/methylene chloride =1/1) to yield 5-hydroxy-6-methoxy-2-(1-methylethyl)benzofuran (20 mg) as crystals.

후처리

  1. extractionThe separated oil was extracted with methylene chloride
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated in vacuo
  5. customThe residue was purified by column chromatography on silica gel (n-hexane/methylene chloride =1/1)

출처 및 근거

ORD 기록
ord-41ac6b771af64590ad03b6e1d14da17b
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05043354

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