Water → HCID 86613843, 화합물

HRID 2249393노트

반응식

HRID 2249393 반응식
C([NH:4][C:5]1[CH:10]=[C:9]([I:11])[N:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[C:6]=1[Cl:16])(=O)C.C(Cl)(=O)C.O>CO>[NH2:4][C:5]1[CH:10]=[C:9]([I:11])[N:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[C:6]=1[Cl:16]

참가 물질

5

반응물 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 86613844HCID 86613844, 화합물

생성물 1

HCID 86613843HCID 86613843, 화합물수율 78.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To solution of 4-acetylamino-3-chloro-6-iodopyridine-2-carboxylic acid, methyl ester (5.0 g, 14 mmol) in methanol (25 mL) was added acetyl chloride (1 mL) and the solution heated under reflux for 1 hour. The solution was cooled and water (25 mL) added and the precipitate was collected. Recrystallization from methanol gave 4-amino-3-chloro-6-iodopyridine-2-carboxylic acid, methyl ester (3.5 g, 11 mmol) mp 152-153° C.

후처리

  1. temperaturethe solution heated
  2. temperatureunder reflux for 1 hour
  3. temperatureThe solution was cooled
  4. customthe precipitate was collected
  5. customRecrystallization from methanol

출처 및 근거

ORD 기록
ord-8dbf45017adf4d5485826a09a4f97c34
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07314849B2

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