Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phthalic Anhydride → 7-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)heptanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phthalic Anhydride | HCID 6811 | — |
| 반응물 | 7-Aminoheptanoic acid | HCID 13580 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 7-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)heptanoic acid | HCID 13622635 | 50.8% |
반응 단계
A mixture of phthalic anhydride (5.3 g.) and 7-amino-heptanoic acid (5.8 g.) was heated at 185°-190° C. for 40 minutes and then cooled. The cooled partially solidified product was dissolved in ethyl acetate and the solution washed several times with dilute HCl. The organic layer was dried (MgSO4), filtered and evaporated to dryness and the residue recrystallized from acetic acid to give 7-phthalimidoheptanoic acid (5 g.), m.p. 112°-115° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04234735 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-69f78c92517845a3a70f96df5c84e7fd |
| 출처 메모 | uspto-grants-1980_11 |