Cyclopropylamine → HCID 59639540, 화합물

HRID 2249842노트

반응식

HRID 2249842 반응식
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.C[Al](C)C.[F:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:11]=1[N:17]1[C:22]2[N:23]=[C:24]([NH:35][CH2:36][C:37](OC)=[O:38])[N:25]=[C:26]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=3[CH3:34])[C:21]=2[CH:20]=[CH:19][C:18]1=[O:41]>>[CH:1]1([NH:4][C:37](=[O:38])[CH2:36][NH:35][C:24]2[N:25]=[C:26]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=3[CH3:34])[C:21]3[CH:20]=[CH:19][C:18](=[O:41])[N:17]([C:11]4[C:12]([F:16])=[CH:13][CH:14]=[CH:15][C:10]=4[F:9])[C:22]=3[N:23]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 3

HCID 69828CyclopropylamineHCID 16682925TrimethylaluminumHCID 59639612HCID 59639612, 화합물

생성물 1

HCID 59639540HCID 59639540, 화합물

실험 절차

Following the procedure outlined in Example 193, cyclopropylamine (0.23 mL, 3.3 mmol), trimethylaluminum (1.7 mL, 3.3 mmol) and the product of Example 190 (150 mg, 0.33 mmol) were reacted to give the desired product, 20 mg (13%). LC-MS: 480.0 (MH+, m/z), 1.89 (Rt, min).

출처 및 근거

ORD 기록
ord-badacca2cf784123a22cca1582136e43
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07314881B2

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