4-Aminotetrahydropyran → HCID 59639536, 화합물

HRID 2250092노트

반응식

HRID 2250092 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1.[NH2:31][CH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12]([NH:31][CH:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1

참가 물질

3

반응물 2

HCID 4192234-AminotetrahydropyranHCID 59639608HCID 59639608, 화합물

생성물 1

HCID 59639536HCID 59639536, 화합물수율 90%

실험 절차

Following the general procedure outlined in Example 126, the product of Example 121 (150 mg, 0.35 mmol), and 4-aminotetrahydropyran (179 mg, 1.77 mmol) were reacted to give the crude material, which was purified as described in Example 198 to give the desired product 140 mg (90%). LC-MS: 445.4 (MH+, m/z), 2.27 (Rt, min).

후처리

  1. customto give the crude material, which
  2. customwas purified

출처 및 근거

ORD 기록
ord-1c722972d7e64edaa3af6c44aff41545
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07314934B2

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