Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phthalimide → 2-(2-Oxocyclohexyl)isoindole-1,3-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phthalimide | HCID 6809 | — |
| 반응물 | 2-Chlorocyclohexanone | HCID 13203 | — |
| 생성물 | 2-(2-Oxocyclohexyl)isoindole-1,3-dione | HCID 322601 | — |
반응 단계
The amine required as precursor was prepared in accordance with GB1131191. 2-Chlorocyclohexanone was reacted with phthalimide to give 2-(2-oxocyclohexyl)isoindole-1,3-dione, which was ketalized with ethylene glycol in the presence of para-toluenesulfonic acid, giving 2-(1,4-dioxaspiro[4.5]dec-6-yl)isoindole-1,3-dione. Treatment with hydrazine hydrate to remove the phthalimideradical gave the desired 1,4-dioxaspiro[4.5]dec-6-ylamine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07317033B2 |
| 출처 데이터셋 | uspto-grants-2008_01 |
| ORD ID | ord-0bd316679de54a07bf16492839134f58 |
| 출처 메모 | uspto-grants-2008_01 |