5-Methylfuran-2-carbonyl chloride → 5-Methyl-furan-2-carboxylic acid (4-methoxy-7-phenyl-benzothiazol-2-yl)-amide
반응식
[NH2:1][C:2]1[S:3][C:4]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:9][CH:8]=[C:7]([O:17][CH3:18])[C:5]=2[N:6]=1.[CH3:19][C:20]1[O:24][C:23]([C:25](Cl)=[O:26])=[CH:22][CH:21]=1>>[CH3:18][O:17][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:25]([C:23]3[O:24][C:20]([CH3:19])=[CH:21][CH:22]=3)=[O:26])[S:3][C:4]=2[C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:9][CH:8]=1참가 물질
3
실험 절차
Using 2-amino-4-methoxy-7-phenyl-benzothiazole and freshly prepared 5-methyl-furan-2-carboxylic acid chloride the title compound was obtained crude, which was chromatographed over SiO2 (Merck 230-400 mesh) eluting with nHexane/EtOAc (4:1), to afford the pure title compound as a pale yellow solid (67% yield), MS: m/e=364.0 (M+).
출처 및 근거
- ORD 기록
- ord-313b1aad481d4c0f863855e7c124ca9d
- 출처 데이터셋
- uspto-grants-2008_01
- 특허 번호
- US07317007B2
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