Triethylamine → benzoic acid N'-[2-(2-sec-butyl-phenoxy)-acetyl]-N'-isopropyl-hydrazide

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide	HCID 15908	—
반응물	1-Benzoyl-2-isopropylhydrazine	HCID 18869	—
반응물	1-Hydroxybenzotriazole	HCID 75771	—
반응물	(2-Sec-butylphenoxy)acetic acid	HCID 3365714	—
용매	Dimethylformamide	HCID 6228	—
생성물	benzoic acid N'-[2-(2-sec-butyl-phenoxy)-acetyl]-N'-isopropyl-hydrazide	HCID 11566858	36.4%

반응 단계

A solution of (2-sec-butyl-phenoxy)-acetic acid (193 mg, 0.93 mmol), and benzoic acid N′-isopropyl-hydrazide (150 mg, 0.842 mmol) in DMF (5 ml), was treated with triethylamine (0.352 ml, 2.52 mmol), HOBT (136 mg, 1.00 mmol), and EDCI (194 mg, 1.00 mmol) for 12 hours at room temperature. The reaction mixture was partitioned between 1N HCl and DCM. The organic layer was successively washed with 1N NaOH and brine, then dried over sodium sulfate, filtered, and concentrated. The crude was absorbed on silica and purified on a silica gel column with 50% ethyl acetate/hexanes to afford the product as a white solid (113 mg, 33%). MS m/e 369.32 (M+H+)

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07317125B2
출처 데이터셋	uspto-grants-2008_01
ORD ID	ord-fcb937a1d1344f42b2833a0eaa607652
출처 메모	uspto-grants-2008_01