Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → 2-Indancarboxylic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | 2,2-Dicarboethoxy-indane | HCID 11010777 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Indancarboxylic Acid | HCID 575777 | 71% |
반응 단계
Dissolve 2,2-dicarboethoxy-indan (5.67 g, 21.7 mmol) in ethanol (150 mL). Add 1N lithium hydroxide (50 mL) and stir overnight at room temperature. Reflux for 1 hour and concentrate the solution in vacuo. Partition between ethyl acetate and 6N hydrochloric acid. Separate the organic phase and wash with brine. Dry (MgSO4) and evaporate the solvent in vacuo to give an off-white solid. Distill (120°-160° C. @0.2-0.5 mmHg) to give 2-carboxy-indan (2.5 g, 71%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428158 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-288d66e56e5748a3accfe02165bd1989 |
| 출처 메모 | uspto-grants-1995_06 |