1-[(1R)-1-cyclopropylpropyl]-3,5-dichloro-2(1H)-pyrazinone → HCID 10274880, 화합물

HRID 2251014노트

반응식

HRID 2251014 반응식
Cl[C:2]1[C:3](=[O:15])[N:4]([C@@H:9]([CH:12]2[CH2:14][CH2:13]2)[CH2:10][CH3:11])[CH:5]=[C:6]([Cl:8])[N:7]=1.Cl.[Br:17][C:18]1[CH:19]=[C:20]([O:27][CH3:28])[CH:21]=[C:22]2[C:26]=1[NH:25][CH2:24][CH2:23]2>>[Br:17][C:18]1[CH:19]=[C:20]([O:27][CH3:28])[CH:21]=[C:22]2[C:26]=1[N:25]([C:2]1[C:3](=[O:15])[N:4]([C@@H:9]([CH:12]3[CH2:14][CH2:13]3)[CH2:10][CH3:11])[CH:5]=[C:6]([Cl:8])[N:7]=1)[CH2:24][CH2:23]2

참가 물질

3

반응물 2

HCID 184527991-[(1R)-1-cyclopropylpropyl]-3,5-dichloro-2(1H)-pyrazinoneHCID 184528177-Bromo-5-methoxyindoline hydrochloride

생성물 1

HCID 10274880HCID 10274880, 화합물

실험 절차

Prepared in a similar fashion as described for Example 413 using 3,5-dichloro-1-[(1R)-1-cyclopropylpropyl]-2(1H)-pyrazinone and 7-bromo-5-methoxyindoline hydrochloride as the starting materials. mp 138-140° C.; 1H NMR (300 MHz, CDCl3): δ 6.94 (s, 1 H), 6.89 (d, J=2.2 Hz, 1H), 6.75 (d, J=2.5 Hz, 1 H), 4.34-4.24 (m, 2 H), 4.10-4.01 (m, 1 H), 3.76 (s, 3 H), 3.09 (t, J=7.9 Hz, 2 H), 1.91-1.74 (m, 2 H), 1.06-0.98 (m, 1 H), 0.95-0.86 (m, 3 H), 0.79-0.72 (m, 1 H), 0.53-0.44 (m, 2 H), 0.35-0.24 (m, 1 H); HRMS (CI) calcd for C19H22N3O2BrCl (M+H)+: 438.0584; found m/z 438.0570.

후처리

  1. customPrepared in a similar fashion

출처 및 근거

ORD 기록
ord-e10243d68699451e842ab7e0f0d64eec
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07319100B2

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