Potassium Carbonate → 8-{2-[2-(2-Methyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl}-6,7-dihydro-5H-1,4,8a-triaza-s-indacene

HRID 2251126노트

반응식

HRID 2251126 반응식
[N:1]1[N:12]2[C:4]([N:5]=[C:6]3[C:10](=[C:11]2[C:13]2[CH:14]=[CH:15][C:16]4[O:20][C:19]([CH2:21][CH2:22]OS(C)(=O)=O)=[CH:18][C:17]=4[CH:28]=2)[CH2:9][CH2:8][CH2:7]3)=[CH:3][CH:2]=1.[CH3:29][CH:30]1[CH2:34][CH2:33][CH2:32][NH:31]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:29][CH:30]1[CH2:34][CH2:33][CH2:32][N:31]1[CH2:22][CH2:21][C:19]1[O:20][C:16]2[CH:15]=[CH:14][C:13]([C:11]3[N:12]4[C:4](=[CH:3][CH:2]=[N:1]4)[N:5]=[C:6]4[C:10]=3[CH2:9][CH2:8][CH2:7]4)=[CH:28][C:17]=2[CH:18]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 130032-MethylpyrrolidineHCID 58587719methanesulfonic acid 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzo-furan-2-yl]-ethyl ester

생성물 1

HCID 116252098-{2-[2-(2-Methyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl}-6,7-dihydro-5H-1,4,8a-triaza-s-indacene

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
70 °C

실험 절차

Methanesulfonic acid 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzo-furan-2-yl]-ethyl ester (0.085 mmol) was dissolved in acetonitrile (2 ml) followed by addition of 2-methylpyrrolidine (0.85 mmol) and potassium carbonate (0.425 mmol) and heated to 70° C. for 24 hours. The reaction was cooled, filtered and concentrated. The residue was purified via preparative HPLC to give the title compound.

후처리

  1. temperatureThe reaction was cooled
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customThe residue was purified via preparative HPLC

출처 및 근거

ORD 기록
ord-b8341a033889438db7344175aaddd330
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07319103B2

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