Ethanol → Ethyl 3-methyl-3-azabicyclo[3.1.0]hexane-1-carboxylate
반응식
Cl.Cl.[CH2:3]([O:5][C:6]([C:8]12[CH2:13][CH:12]1[CH2:11][N:10]([CH3:14])[CH2:9]2)=N)[CH3:4].C([OH:17])C>O>[CH2:3]([O:5][C:6]([C:8]12[CH2:13][CH:12]1[CH2:11][N:10]([CH3:14])[CH2:9]2)=[O:17])[CH3:4]참가 물질
4
실험 절차
Crude 3-methyl-3-azabicyclo[3.1.0]hexane-1-carboximidic acid ethyl ester dihydrochloride (obtained as described below) is boiled under reflux for 3 hours in 30 ml of ethanol and 0.6 ml of water. After evaporation, the resultant residue is made alkaline with an aqueous sodium bicarbonate solution. Extraction with methylene chloride gives the title compound (M.Pt. of napthalene-1,5-disulphonate 161°-165°).
후처리
- customAfter evaporation
- extractionExtraction with methylene chloride
출처 및 근거
- ORD 기록
- ord-c5c1528743eb49af88960be021bdc813
- 출처 데이터셋
- uspto-grants-1980_11
- 특허 번호
- US04235921
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