Water → 3-Methyl-3-azabicyclo[3.1.0]hexane-1-carboxylic acid

반응식

[CH3:1][N:2]1[CH2:7][CH:6]2[C:4]([C:8]#N)([CH2:5]2)[CH2:3]1.[OH-:10].[K+].[OH2:12]>>[CH3:1][N:2]1[CH2:7][CH:6]2[C:4]([C:8]([OH:12])=[O:10])([CH2:5]2)[CH2:3]1

참가 물질

반응물 3

HCID 962Water

HCID 14797Potassium Hydroxide

HCID 121996863-Methyl-3-azabicyclo[3.1.0]-hexane-1-carbonitrile

생성물 1

HCID 233291843-Methyl-3-azabicyclo[3.1.0]hexane-1-carboxylic acid

실험 절차

A solution of 10 g of 3-methyl-3-azabicyclo[3.1.0]-hexane-1-carbonitrile is 60 ml of saturated ethanolic KOH and 20 ml of water is boiled under reflux for 15 hours. After neutralization with hydrochloric acid the mixture is evaporated and the title compound is extracted from the resultant dried residue with hot absolute ethanol (M.P. 193°-195°).

후처리

temperatureunder reflux for 15 hours
customAfter neutralization with hydrochloric acid the mixture is evaporated
extractionthe title compound is extracted from the resultant dried residue with hot absolute ethanol (M.P. 193°-195°)

출처 및 근거

ORD 기록: ord-1f7c16e7d879450b9f9cf03cf27fb9d0
출처 데이터셋: uspto-grants-1980_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04235921

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