Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[3-(3-{(5-Isopropylpyridin-2-yl)[4-(trifluoromethoxy)benzyl]amino}propyl)phenoxy]-2-methylpropanoic acid

HRID 2251547

반응식

HRID 2251547 반응식
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][C:29]([F:32])([F:31])[F:30])=[CH:24][CH:23]=2)[CH2:11][CH2:12][CH2:13][C:14]2[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=2)=[N:8][CH:9]=1)([CH3:3])[CH3:2].C([O:35][C:36](=[O:41])[C:37](Br)([CH3:39])[CH3:38])C>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([O:28][C:29]([F:32])([F:30])[F:31])=[CH:26][CH:27]=2)[CH2:11][CH2:12][CH2:13][C:14]2[CH:15]=[C:16]([CH:17]=[CH:18][CH:19]=2)[O:20][C:37]([CH3:39])([CH3:38])[C:36]([OH:41])=[O:35])=[N:8][CH:9]=1)([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 596431683-(3-{(5-Isopropylpyridin-2-yl)[4-(trifluoromethoxy)benzyl]amino}propyl)phenol

생성물 1

HCID 596433492-[3-(3-{(5-Isopropylpyridin-2-yl)[4-(trifluoromethoxy)benzyl]amino}propyl)phenoxy]-2-methylpropanoic acid

실험 절차

Similarly prepared by alkylation of 3-(3-{(5-isopropylpyridin-2-yl)[4-(trifluoromethoxy)benzyl]amino}propyl)phenol with ethyl-2-bromo-isobutyrate followed by standard base-mediated hydrolysis.

후처리

  1. customfollowed by standard base-mediated hydrolysis

출처 및 근거

ORD 기록
ord-ff168f1c7afa4e61afa0bb6a62fb5b6b
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07319104B2

연결된 노트

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