2-Bromo-1-(3,4-difluorophenyl)ethan-1-one → 2-[4-(2-{[4-(3,4-Difluorophenyl)-1,3-thiazol-2-yl][4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoic acid
반응식
[NH2:1][C:2]([N:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=1)[CH2:5][CH2:6][C:7]1[CH:21]=[CH:20][C:10]([O:11][C:12]([CH3:19])([CH3:18])[C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=1)=[S:3].[F:33][C:34]1[CH:35]=[C:36]([CH:41]=[CH:42][C:43]=1[F:44])[C:37](=O)[CH2:38]Br>>[F:33][C:34]1[CH:35]=[C:36]([C:37]2[N:1]=[C:2]([N:4]([CH2:22][C:23]3[CH:24]=[CH:25][C:26]([C:29]([F:32])([F:30])[F:31])=[CH:27][CH:28]=3)[CH2:5][CH2:6][C:7]3[CH:21]=[CH:20][C:10]([O:11][C:12]([CH3:18])([CH3:19])[C:13]([OH:15])=[O:14])=[CH:9][CH:8]=3)[S:3][CH:38]=2)[CH:41]=[CH:42][C:43]=1[F:44]참가 물질
3
반응물 2
생성물 1
실험 절차
Similarly prepared from ethyl 2-[4-(2-{(aminocarbonothioyl)[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate and 3,4-difluorophenacyl bromide.
출처 및 근거
- ORD 기록
- ord-9e78c80345264e9ea0a31be760ae5d0a