2-Bromo-1-(3,4-difluorophenyl)ethan-1-one → 2-[4-(2-{[2,4-Bis(trifluoromethyl)benzyl][4-(3,4-difluorophenyl)-1,3-thiazol-2-yl]amino}ethyl)phenoxy]-2-methylpropanoic acid
반응식
[NH2:1][C:2]([N:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][C:24]=1[C:33]([F:36])([F:35])[F:34])[CH2:5][CH2:6][C:7]1[CH:21]=[CH:20][C:10]([O:11][C:12]([CH3:19])([CH3:18])[C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=1)=[S:3].[F:37][C:38]1[CH:39]=[C:40]([CH:45]=[CH:46][C:47]=1[F:48])[C:41](=O)[CH2:42]Br>>[F:35][C:33]([F:34])([F:36])[C:24]1[CH:25]=[C:26]([C:29]([F:30])([F:32])[F:31])[CH:27]=[CH:28][C:23]=1[CH2:22][N:4]([C:2]1[S:3][CH:42]=[C:41]([C:40]2[CH:45]=[CH:46][C:47]([F:48])=[C:38]([F:37])[CH:39]=2)[N:1]=1)[CH2:5][CH2:6][C:7]1[CH:21]=[CH:20][C:10]([O:11][C:12]([CH3:18])([CH3:19])[C:13]([OH:15])=[O:14])=[CH:9][CH:8]=1참가 물질
3
반응물 2
생성물 1
실험 절차
Similarly prepared from ethyl 2-[4-(2-{(aminocarbonothioyl)[2,4-bis(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate and 3,4-difluorophenacyl bromide.
출처 및 근거
- ORD 기록
- ord-2015b4c68b3645daa3b2f0a730308850