2-Bromo-1-(4-fluorophenyl)ethan-1-one → 2-[4-(2-{[2,4-Bis(trifluoromethyl)benzyl][4-(4-fluorophenyl)-1,3-thiazol-2-yl]amino}ethyl)phenoxy]-2-methylpropanoic acid

HRID 2251590

반응식

HRID 2251590 반응식
[NH2:1][C:2]([N:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][C:24]=1[C:33]([F:36])([F:35])[F:34])[CH2:5][CH2:6][C:7]1[CH:21]=[CH:20][C:10]([O:11][C:12]([CH3:19])([CH3:18])[C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=1)=[S:3].[F:37][C:38]1[CH:47]=[CH:46][C:41]([C:42](=O)[CH2:43]Br)=[CH:40][CH:39]=1>>[F:35][C:33]([F:34])([F:36])[C:24]1[CH:25]=[C:26]([C:29]([F:32])([F:31])[F:30])[CH:27]=[CH:28][C:23]=1[CH2:22][N:4]([C:2]1[S:3][CH:43]=[C:42]([C:41]2[CH:46]=[CH:47][C:38]([F:37])=[CH:39][CH:40]=2)[N:1]=1)[CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:11][C:12]([CH3:19])([CH3:18])[C:13]([OH:15])=[O:14])=[CH:20][CH:21]=1

참가 물질

3

반응물 2

HCID 967492-Bromo-1-(4-fluorophenyl)ethan-1-oneHCID 59643200Ethyl 2-[4-(2-{(aminocarbonothioyl)[2,4-bis(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate

생성물 1

HCID 596432682-[4-(2-{[2,4-Bis(trifluoromethyl)benzyl][4-(4-fluorophenyl)-1,3-thiazol-2-yl]amino}ethyl)phenoxy]-2-methylpropanoic acid

실험 절차

Similarly prepared from ethyl 2-[4-(2-{(aminocarbonothioyl)[2,4-bis(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate and 4-fluorophenacyl bromide.

출처 및 근거

ORD 기록
ord-96e72e58091447eebf01ea6742ea79a1
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07319104B2

연결된 노트

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