5-Bromo-1-indanone → 1-methyl-5-(1-oxo-2,3-dihydro-1H-inden-5-yl)-1H-pyrrole-2-carbonitrile

반응식

Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[CH3:12][N:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[C:18]#[N:19]>>[CH3:12][N:13]1[C:17]([C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[C:7](=[O:11])[CH2:6][CH2:5]3)=[CH:16][CH:15]=[C:14]1[C:18]#[N:19]

참가 물질

반응물 2

HCID 5206955-Bromo-1-indanone

HCID 20641111-Methylpyrrole-2-carbonitrile

생성물 1

HCID 249870181-methyl-5-(1-oxo-2,3-dihydro-1H-inden-5-yl)-1H-pyrrole-2-carbonitrile

실험 절차

The title compound was prepared from 5-bromo-1-indanone and 1-methyl-2-cyanopyrrole according to the coupling procedure as described in example 1. MS (ESI) m/z 237; HRMS: calcd for C15H12N2O+H+, 237.1022; found (ESI, [M+H]+), 237.1003; Anal. Calcd for C15H12N2O: C, 76.25; H, 5.12; N, 11.86. Found: C, 75.99; H, 4.92; N, 11.80.

출처 및 근거

ORD 기록: ord-50db46f81c9c4906b8de4e8456125267
출처 데이터셋: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07319152B2

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