3-Chloro-2-methylaniline → 2-{[(3-Chloro-2-methylphenyl)imino]methyl}phenol

HRID 225179

반응식

HRID 225179 반응식
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:10][C:11]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:12]=1[NH2:13]>C(O)C>[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[N:13][C:12]1[CH:14]=[CH:15][CH:16]=[C:17]([Cl:18])[C:11]=1[CH3:10]

참가 물질

4

반응물 2

HCID 68943-Chloro-2-methylanilineHCID 6998Salicylaldehyde

생성물 1

HCID 2963922-{[(3-Chloro-2-methylphenyl)imino]methyl}phenol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

o-Hydroxybenzaldehyde (0.20 mole) was treated with 2-methyl-3-chloroaniline (0.20 mole) with vigorous stirring in a 1 liter Erlenmeyer flask. After 15 mins., 33 cc of 95% ethanol was added and the reaction mixture was stirred vigorously for an additional 45 mins. The reaction mixture was left standing at room temperature for 10 min., then it was placed in an ice-bath for 0.5 hour. The crystals which formed were collected, washed with 95% ethanol, and air dried. Recrystallization from 85% ethanol gave N-(o-hydroxybenzylidene)-2-methyl-3-chloroaniline. m.p. 95°-97° C.

후처리

  1. stirringthe reaction mixture was stirred vigorously for an additional 45 mins
  2. waitThe reaction mixture was left
  3. waitstanding at room temperature for 10 min.
  4. waitit was placed in an ice-bath for 0.5 hour
  5. customThe crystals which formed
  6. customwere collected
  7. washwashed with 95% ethanol, and air
  8. customdried
  9. customRecrystallization from 85% ethanol

출처 및 근거

ORD 기록
ord-c4cad60feea44fb8b0ecc89b55284f0c
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04235929

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