Ether hydrochloride → (R)-2-Fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

HRID 2251890노트

반응식

HRID 2251890 반응식
[ClH:1].C(OCC)C.[F:7][C:8]1[CH:41]=[CH:40][C:11]2[N:12]([CH2:21][C@H:22]3[CH2:26][CH2:25][CH2:24][N:23]3[CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([N:35]4[CH2:39][CH2:38][CH2:37][CH2:36]4)=[CH:31][CH:30]=3)[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[O:15][CH2:16][C:10]=2[CH:9]=1>ClCCl>[ClH:1].[ClH:1].[F:7][C:8]1[CH:41]=[CH:40][C:11]2[N:12]([CH2:21][C@H:22]3[CH2:26][CH2:25][CH2:24][N:23]3[CH2:27][CH2:28][C:29]3[CH:30]=[CH:31][C:32]([N:35]4[CH2:36][CH2:37][CH2:38][CH2:39]4)=[CH:33][CH:34]=3)[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[O:15][CH2:16][C:10]=2[CH:9]=1

참가 물질

4

반응물 2

HCID 10953452Ether hydrochlorideHCID 59644017(R)-2-fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine

생성물 1

HCID 69199662(R)-2-Fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

20 ml of 2 M hydrogen chloride/diethyl ether was added to a solution of (R)-2-fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (2.29 g) in dichloromethane (30 ml), and they were stirred together for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was solidified by stirring it in hexane. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a brown solid (2.17 g, 81%).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. stirringby stirring it in hexane
  3. customThe solid thus precipitated
  4. filtrationwas taken by the filtration

출처 및 근거

ORD 기록
ord-2d74ee5d69dc4e049fc1c5f8d437f749
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07320973B2

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