Triethylamine → HCID 22934159, 화합물

HRID 2251892노트

반응식

HRID 2251892 반응식
[N:1]1([C:6]2[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:10][OH:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:22][S:23](Cl)(=[O:25])=[O:24].C(=O)([O-])O.[Na+]>ClCCl>[S:23]([O:11][CH2:10][CH2:9][C:8]1[CH:12]=[CH:13][CH:14]=[C:6]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:7]=1)(=[O:25])(=[O:24])[CH3:22]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 516892Sodium BicarbonateHCID 574734173-Pyrrolidinophenethyl Alcohol

생성물 1

HCID 22934159HCID 22934159, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

3-Pyrrolidinophenethyl alcohol was dissolved in dichloromethane (20 ml). Triethylamine (3.7 ml, 26.7 ml) and methanesulfonyl chloride (1.9 ml, 24.5 mmol) were added to the obtained solution at 0° C., and they were stirred overnight. The reaction mixture was distributed into 5% aqueous sodium hydrogencarbonate solution and dichloromethane. The organic layer was dried and the solvent was evaporated under reduced pressure. The residue was subjected to the silica gel column chromatography. After the elution with hexane and ethyl acetate (7:3), suitable fractions were collected and the solvent was evaporated under reduced pressure to obtain 3-pyrrolidinophenethyl mesylate in the form of a white solid (5.13 g, 87%).

후처리

  1. customThe organic layer was dried
  2. customthe solvent was evaporated under reduced pressure
  3. washAfter the elution with hexane and ethyl acetate (7:3), suitable fractions
  4. customwere collected
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-d885acfafcdc4b0ab878f6f0f8b1357b
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07320973B2

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