Ether hydrochloride → (r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]-dibenzo[b,e][1,4]oxazepine dihydrochloride

HRID 2251901노트

반응식

HRID 2251901 반응식
[ClH:1].C(OCC)C.[N:7]1([C:12]2[CH:13]=[C:14]([CH:38]=[CH:39][CH:40]=2)[CH2:15][CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][C@@H:18]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)[CH2:11][CH2:10][CH2:9][CH2:8]1>ClCCl>[ClH:1].[ClH:1].[N:7]1([C:12]2[CH:13]=[C:14]([CH:38]=[CH:39][CH:40]=2)[CH2:15][CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][C@@H:18]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)[CH2:11][CH2:10][CH2:9][CH2:8]1

참가 물질

4

반응물 2

HCID 10953452Ether hydrochlorideHCID 12990604(r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine

생성물 1

HCID 69201019(r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]-dibenzo[b,e][1,4]oxazepine dihydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2.0 ml of 2 M hydrogen chloride/diethyl ether was added to a solution of (R)-5,11-dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (208 mg) in dichloromethane (2 ml), and they were stirred together for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was solidified by stirring it in hexane. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a light brown solid (220 mg, 91%).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. stirringby stirring it in hexane
  3. customThe solid thus precipitated
  4. filtrationwas taken by the filtration

출처 및 근거

ORD 기록
ord-3e3623e7f1c44c4aa5e093cb67b95be7
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07320973B2

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