1,1'-Carbonyldiimidazole → N-(6-hydroxy-6,6-diphenyl-hexyl)-3-pyridin-3-yl-acrylamide

HRID 2251924노트

반응식

HRID 2251924 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9]([OH:11])=O)[CH:2]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[OH:24][C:25]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH2:31]>C1COCC1>[OH:24][C:25]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:9](=[O:11])[CH:8]=[CH:7][C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 682631,1'-CarbonyldiimidazoleHCID 1019843-(3-Pyridinyl)-2-propenoic acidHCID 17940778HCID 17940778, 화합물

생성물 1

HCID 54570481N-(6-hydroxy-6,6-diphenyl-hexyl)-3-pyridin-3-yl-acrylamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Batch size: 3.2 g (21.6 mmol) 3-(3-pyridyl)-acrylic acid, 3.85 g (23.8 mmol) CDI and 4.2 g (25.9 mmol) 6-hydroxy-6,6-diphenyl-hexylamine in 60 ml abs. THF.

출처 및 근거

ORD 기록
ord-1d81e9fc322c4ffe82b03339ff94041f
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07320993B1

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