Benzene → Oxazolidine, 3-(dichloroacetyl)-2,2-dimethyl-

HRID 225224

반응식

HRID 225224 반응식
[CH3:1][C:2]1([CH3:7])[NH:6][CH2:5][CH2:4][O:3]1.C1C=CC=CC=1.C(N(CC)CC)C.[Cl:21][CH:22]([Cl:26])[C:23](Cl)=[O:24]>O>[CH3:1][C:2]1([CH3:7])[N:6]([C:23](=[O:24])[CH:22]([Cl:26])[Cl:21])[CH2:5][CH2:4][O:3]1

참가 물질

6

반응물 4

HCID 241BenzeneHCID 6593Dichloroacetyl chlorideHCID 8471TriethylamineHCID 5506972,2-Dimethyl-oxazolidine

생성물 1

HCID 11492198Oxazolidine, 3-(dichloroacetyl)-2,2-dimethyl-

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Five and one-tenth (5.1 g.) grams of 2,2-dimethyl oxazolidine dissolved in 50 ml. of benzene was treated with 5.5 g. of triethylamine and 7.4 g. of dichloroacetyl chloride was added dropwise with stirring and cooling in an ice bath. The mixture was poured into water, the benzene solution separated, dried over anhydrous magnesium sulfate and the solvent stripped under vacuum. The product was a waxy solid which had a melting point of 113°-115° C. on recrystallization from diethyl ether.

후처리

  1. temperaturecooling in an ice bath
  2. customthe benzene solution separated
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customon recrystallization from diethyl ether

출처 및 근거

ORD 기록
ord-8c374c1c40bf439d9bf38fefb1b35619
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04236011

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