Pyridinium chloride → 5-[2-(2,4-Difluorophenyl)ethenyl]-2-i-propyl-1,3-benzenediol

반응식

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[CH:10][C:11]1[CH:16]=[C:15]([O:17]C)[C:14]([CH:19]([CH3:21])[CH3:20])=[C:13]([O:22]C)[CH:12]=1.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[CH:10][C:11]1[CH:12]=[C:13]([OH:22])[C:14]([CH:19]([CH3:20])[CH3:21])=[C:15]([OH:17])[CH:16]=1

참가 물질

반응물 2

HCID 10176127Pyridinium chloride

HCID 690999381-(2,4-Difluorophenyl)-2-(3,5-dimethoxy-4-i-propylphenyl)ethene

생성물 1

HCID 668431925-[2-(2,4-Difluorophenyl)ethenyl]-2-i-propyl-1,3-benzenediol수율 44%

실험 절차

This material was prepared from 1-(2,4-difluorophenyl)-2-(3,5-dimethoxy-4-i-propylphenyl)ethene and pyridine hydrochloride in 44% yield in the same way as described in example 34. 1HNMR (CDCl3, ppm): δ 1.41 (d, J=7.1 Hz, 6H), 3.49 (qint, J=7.1 Hz, 1H), 4.78 (br, 2H), 6.54 (s, 2H), 6.69-7.02 (m, 3H), 7.13 (d, J=16 Hz, 1H), 7.41-7.75 (m, 1H).

출처 및 근거

ORD 기록: ord-91750fdfd5b84dc69aaed789b293e11e
출처 데이터셋: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07321050B2

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