Pyridinium chloride → 2-i-Propyl-5-[2-(2,4,6-trifluorophenyl)ethenyl]-1,3-benzenediol

반응식

C[O:2][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][C:16]2[C:21]([F:22])=[CH:20][C:19]([F:23])=[CH:18][C:17]=2[F:24])[CH:6]=[C:7]([O:12]C)[C:8]=1[CH:9]([CH3:11])[CH3:10].Cl.N1C=CC=CC=1>>[CH:9]([C:8]1[C:3]([OH:2])=[CH:4][C:5]([CH:14]=[CH:15][C:16]2[C:21]([F:22])=[CH:20][C:19]([F:23])=[CH:18][C:17]=2[F:24])=[CH:6][C:7]=1[OH:12])([CH3:11])[CH3:10]

참가 물질

반응물 2

HCID 10176127Pyridinium chloride

HCID 690997671-(3,5-Dimethoxy-4-i-propylphenyl)-2-(2,4,6-trifluorophenyl)ethene

생성물 1

HCID 668427312-i-Propyl-5-[2-(2,4,6-trifluorophenyl)ethenyl]-1,3-benzenediol수율 14%

실험 절차

This material was prepared from 1-(3,5-dimethoxy-4-i-propylphenyl)-2-(2,4,6-trifluorophenyl)ethene and pyridine hydrochloride in 14% yield in the same way as described in example 29. 1HNMR (CDCl3, ppm): δ 1.42 (d, J=7.1 Hz, 6H), 3.50 (qint, J=7.1 Hz, 1H), 4.77 (br, 2H), 6.55 (s, 2H), 6.59-7.24 (m, 4H).

출처 및 근거

ORD 기록: ord-6c31180718bc49149965c23826884678
출처 데이터셋: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07321050B2

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