Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Dimethylamino-3'-trifluoromethylacrylophenone → 2-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 반응물 | HCID 178434678 | HCID 178434678 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 15042084 | — |
반응 단계
A mixture of 24.3 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 150 ml. of glacial acetic acid and 12.2 g. of 3-methyl-5-aminopyrazole-4-carbonitrile is refluxed for 6 hours and then evaporated. The residue is treated as described in Example 1, giving the desired product, m.p. 149°-150° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04236005 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-7e4cf7ca5cff4ce0be2a6e84e95206d3 |
| 출처 메모 | uspto-grants-1980_11 |