3-Dimethylamino-3'-trifluoromethylacrylophenone → 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine

HRID 225239

반응식

HRID 225239 반응식
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.CN(C)[CH:9]=[CH:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=1)=O>C(O)(=O)C>[F:20][C:19]([F:21])([F:22])[C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([C:11]2[N:3]3[N:4]=[CH:5][CH:6]=[C:2]3[N:1]=[CH:9][CH:10]=2)[CH:14]=1

참가 물질

4

반응물 2

HCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenoneHCID 178418806HCID 178418806, 화합물

생성물 1

HCID 197562037-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 8.31 g. of 3-aminopyrazole, 24.32 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone and 100 ml. of glacial acetic acid is refluxed for 8 hours and evaporated in vacuo to an oil. This oil is treated as described in Example 1, giving the desired product, m.p. 103°-104.5° C.

후처리

  1. additionA mixture of 8.31 g
  2. customevaporated in vacuo to an oil
  3. additionThis oil is treated

출처 및 근거

ORD 기록
ord-b7406f825afd4748944c91433263895e
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04236005

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