Pyrazole, 3-amino-4-cyano-5-ethyl- → 2-Ethyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

HRID 225257

반응식

HRID 225257 반응식
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.[NH2:18][C:19]1[C:23](C#N)=[C:22]([CH2:26][CH3:27])[NH:21][N:20]=1>C(O)(=O)C>[CH2:26]([C:22]1[C:23]([C:19]#[N:18])=[C:17]2[N:2]=[CH:3][CH:4]=[C:5]([C:7]3[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=3)[N:20]2[N:21]=1)[CH3:27]

참가 물질

4

반응물 2

HCID 114021Pyrazole, 3-amino-4-cyano-5-ethyl-HCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

생성물 1

HCID 233298372-Ethyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 7.29 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone and 4.08 g. of 3-amino-5-ethylpyrazole-4-carbonitrile in 25 ml. of glacial acetic acid is refluxed for 15 hours and then evaporated to a residue. This residue is treated as described in Example 1, giving the desired product, m.p. 144°-146° C.

후처리

  1. additionA mixture of 7.29 g
  2. customevaporated to a residue
  3. additionThis residue is treated

출처 및 근거

ORD 기록
ord-c3aecf8abc5a4daca57e2691eedcb11d
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04236005

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