3-Dimethylamino-3'-trifluoromethylacrylophenone → 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)-8-bromoimidazo[1,5-a]pyrimidine
반응식
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.NC1[N:20]=[CH:21][NH:22][C:23]=1[Br:24]>C(O)(=O)C>[F:16][C:13]([F:14])([F:15])[C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([C:5]2[N:20]3[CH:21]=[N:22][C:23]([Br:24])=[C:17]3[N:2]=[CH:3][CH:4]=2)[CH:8]=1참가 물질
4
실험 절차
A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 0.01 mole of 4-amino-5-bromoimidazole and 50 ml. of glacial acetic acid is refluxed for 6 hours. The solvent is removed and the residue worked up as for Example 29 to give the product of the example.
후처리
- customThe solvent is removed
- customto give the product of the example
출처 및 근거
- ORD 기록
- ord-275d49dace404ac4a3b38cf9404e6461
- 출처 데이터셋
- uspto-grants-1980_11
- 특허 번호
- US04236005
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