3-amino-1H-pyrazole-4,5-dicarbonitrile → 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile

HRID 225269

반응식

HRID 225269 반응식
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.CC(OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=O.[NH2:42][C:43]1[C:47](C#N)=[C:46]([C:50]#[N:51])[NH:45][N:44]=1>>[C:43]([C:47]1[C:46]([C:50]#[N:51])=[N:45][N:44]2[C:5]([C:7]3[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=3)=[CH:4][CH:3]=[N:2][C:17]=12)#[N:42]

참가 물질

4

반응물 3

HCID 3388303-amino-1H-pyrazole-4,5-dicarbonitrileHCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterHCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

생성물 1

HCID 113704003-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile

실험 절차

A mixture of 4.86 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic and 2.66 g. of 3-aminopyrazole-4,5-dicarbonitrile is refluxed for 10 hours and the solvent removed under reduced pressure. The residue is reacted with trifluoroacetic anhydride to give the product of the example.

후처리

  1. additionA mixture of 4.86 g
  2. customthe solvent removed under reduced pressure
  3. customThe residue is reacted with trifluoroacetic anhydride
  4. customto give the product of the example

출처 및 근거

ORD 기록
ord-8a041eab68fa4b0f9476f8937d90c71f
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04236005

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