Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-amino-1H-imidazole-4-carbonitrile → 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-amino-1H-imidazole-4-carbonitrile | HCID 78777 | — |
| 반응물 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carbonitrile | HCID 15712556 | — |
반응 단계
A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone and 0.01 mole of 4-amino-5-imidazolecarbonitrile in 30 ml. of glacial acetic acid is refluxed for 6 hours. The solvent is removed under reduced pressure and worked up as for Example 29 to give the product as crystals, m.p. 168°-169° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04236005 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-662297a6590c445487fb32c1e108f620 |
| 출처 메모 | uspto-grants-1980_11 |