5-amino-1H-imidazole-4-carbonitrile → 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carbonitrile

HRID 225270

반응식

HRID 225270 반응식
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.[NH2:18][C:19]1[N:20]=[CH:21][NH:22][C:23]=1C#N>C(O)(=O)C>[F:16][C:13]([F:14])([F:15])[C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([C:5]2[N:20]3[CH:21]=[N:22][C:23]([C:19]#[N:18])=[C:17]3[N:2]=[CH:3][CH:4]=2)[CH:8]=1

참가 물질

4

반응물 2

HCID 787775-amino-1H-imidazole-4-carbonitrileHCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

생성물 1

HCID 157125564-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carbonitrile

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone and 0.01 mole of 4-amino-5-imidazolecarbonitrile in 30 ml. of glacial acetic acid is refluxed for 6 hours. The solvent is removed under reduced pressure and worked up as for Example 29 to give the product as crystals, m.p. 168°-169° C.

후처리

  1. customThe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-662297a6590c445487fb32c1e108f620
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04236005

연결된 노트

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