Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2252729생성일: 2026년 10월 27일
Citric Acid → Ethanesulfonic acid [6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-5-(2-methoxy-phenoxy)-[2,2']bipyrimidinyl-4-yl]-amide
https://huagongshe.com/reaction/2252729
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| 반응물 | Ethanesulfonic acid [6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-[2,2]bipyrimidinyl-4-yl]-amide | HCID 59645268 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Ethanesulfonic acid [6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-5-(2-methoxy-phenoxy)-[2,2']bipyrimidinyl-4-yl]-amide | HCID 10240093 | 44.9% |
반응 단계
Ethanesulfonic acid [6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-[2,2]bipyrimidinyl-4-yl]-amide (89 mg) was dissolved in THF (10 ml). Sodium hydride (60 mg) and 2-chloro-5-bromo-pyrimidine (100 mg) were added and the mixture was heated to 75° C. for 48 h, then poured onto water, acidified with solid citric acid and the precipitate was filtered off. The crude material was purified by crystallization from methanol to give ethanesulfonic acid [6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-5-(2-methoxy-phenoxy)-[2,2′]bipyrimidinyl-4-yl]-amide (54 mg) as a white powder. LC-MS: tR: 4.23, [M+H]+: 605.90.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07323465B2 |
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| 출처 데이터셋 | uspto-grants-2008_01 |
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| ORD ID | ord-a89081a8a3864250a685fe7912b922a2 |
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| 출처 메모 | uspto-grants-2008_01 |
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