Dimethylformamide → 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile

HRID 225274

반응식

HRID 225274 반응식
Br[C:2]1[CH:3]=[N:4][N:5]2[C:10]([C:11]3[CH:12]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:14]=[CH:15][CH:16]=3)=[CH:9][CH:8]=[N:7][C:6]=12.[CH3:21][N:22](C)C=O>>[F:18][C:17]([F:20])([F:19])[C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([C:10]2[N:5]3[N:4]=[CH:3][C:2]([C:21]#[N:22])=[C:6]3[N:7]=[CH:8][CH:9]=2)[CH:12]=1

참가 물질

3

반응물 2

HCID 6228DimethylformamideHCID 114733173-Bromo-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine

생성물 1

HCID 27410147-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile

실험 절차

A mixture of 0.95 g. of 3-bromo-7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine, 0.45 g. cuprous cyanide and 25 ml. of dimethylformamide is refluxed for 16 hours. Evaporation of the reaction mixture gave a residue which was triturated with methylene chloride. The methylene chloride solution is passed through a short column of hydrous magnesium silicate. The effluent is collected and refluxed on a steam bath with gradual addition of n-hexane and the desired nitrile crystallized from solution, m.p. 141°-143° C.

후처리

  1. additionA mixture of 0.95 g
  2. customEvaporation of the reaction mixture
  3. customgave a residue which
  4. customwas triturated with methylene chloride
  5. customThe effluent is collected
  6. temperaturerefluxed on a steam bath with gradual addition of n-hexane
  7. customthe desired nitrile crystallized from solution, m.p. 141°-143° C.

출처 및 근거

ORD 기록
ord-eeabe8c54d2443feb9b80e225e38510f
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04236005

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