1-Chloroethyl chloroformate → 2-[(3-Methylphenyl)methyl]morpholine

반응식

C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)[CH2:9]1)C1C=CC=CC=1.C(N1CCO[C@H](CC2C=CC=C(C=CC3C=NC=CC=3)C=2)C1)(OC(C)(C)C)=O.ClC(OC(Cl)C)=O>>[CH3:21][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[CH2:14][CH:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1

참가 물질

반응물 3

HCID 5213051-Chloroethyl chloroformate

HCID 67073243N-benzyl-2-(3-methylbenzyl)-morpholine

HCID 67073511N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine

생성물 1

HCID 114993552-[(3-Methylphenyl)methyl]morpholine

실험 절차

Example 76 was prepared as described for example 27, but using N-benzyl-2-(3-methylbenzyl)-morpholine, intermediate (a) and 1-chloroethyl chloroformate and was isolated as a colorless oil (38.6 mg).

후처리

customExample 76 was prepared

출처 및 근거

ORD 기록: ord-b171d6b7b08a403f9e20084daf63a2c2
출처 데이터셋: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07323466B2

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