Ethanol → HCID 11360072, 화합물

HRID 2253190노트

반응식

HRID 2253190 반응식
C[O:2][C:3](=[O:25])[CH2:4][NH:5][C:6]([C:8]1[N:9]=[C:10](Cl)[C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7].[OH-].[K+].[CH3:28][CH2:29][OH:30]>>[CH2:29]([O:30][C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:17]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[C:8]([C:6]([NH:5][CH2:4][C:3]([OH:2])=[O:25])=[O:7])[N:9]=1)[CH3:28]

참가 물질

4

반응물 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 86014604HCID 86014604, 화합물

생성물 1

HCID 11360072HCID 11360072, 화합물

실험 절차

A mixture of [(1-Chloro-4-phenyl-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester (177 mg, 0.5 mmol), KOH (325 mg, 5 mmol) and EtOH (10 ml) was stirred at ambient temperature for 90 min before the solvent was evaporated in vacuo. The residue was dissolved in water (10 ml). The solution was acidified by addition of concentrated aqueous HCl and extracted with EtOAc (2×15 ml). The combined organic phases were dried over MgSO4 and concentrated in vacuo to give the title compound as a slightly yellowish solid (169 mg); MS-(+)-ion: M+1=351.0.

후처리

  1. customwas evaporated in vacuo
  2. dissolutionThe residue was dissolved in water (10 ml)
  3. additionThe solution was acidified by addition of concentrated aqueous HCl
  4. extractionextracted with EtOAc (2×15 ml)
  5. dry with materialThe combined organic phases were dried over MgSO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-df827cf25b70424da06694aaa38a7a12
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07323475B2

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