Sulfuric Acid → 1H-Imidazole-4-sulfonic acid, 5-chloro-1-methyl-

반응식

[Cl:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][CH:3]=1.[S:8](=O)(=[O:11])([OH:10])[OH:9]>>[Cl:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[S:8]([OH:11])(=[O:10])=[O:9]

참가 물질

반응물 2

HCID 1118Sulfuric Acid

HCID 701055-chloro-1-methyl-1H-imidazole

생성물 1

HCID 30781001H-Imidazole-4-sulfonic acid, 5-chloro-1-methyl-

실험 절차

33 g (0.28 mol) of 5-chloro-1-methylimidazole in 200 ml of fuming sulfuric acid are heated at 160°-180° C. for 4 hours. After cooling, the reaction mixture is cautiously added to ice. The product crystallizes out from the cold aqueous solution (about 1.5 l). After recrystallizing twice from water, the title compound is obtained in the form of coarse yellowish crystals of melting point 309°-310° C.

후처리

temperatureAfter cooling
additionthe reaction mixture is cautiously added to ice
customThe product crystallizes out from the cold aqueous solution (about 1.5 l)
customAfter recrystallizing twice from water

출처 및 근거

ORD 기록: ord-faf639ffcc1645899c5ac0bf829f29fa
출처 데이터셋: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05232922

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