Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → 5,5-Dimethyl-1-iodo-trans-octen-3-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Trimethylamine oxide | HCID 1145 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Bis(1,2-dimethylpropyl)borane | HCID 192733 | — |
| 반응물 | 5,5-Dimethyl-3-tetrahydropyranyloxy-1-octyne | HCID 53889730 | — |
| 반응물 | Tetrahydrofuranacetic acid water | HCID 86732972 | — |
| 용매 | Diglyme | HCID 8150 | — |
| 생성물 | 5,5-Dimethyl-1-iodo-trans-octen-3-ol | HCID 20465606 | — |
반응 단계
Treatment of 23.8 g. (0.100 mole) of 5,5-dimethyl-3-tetrahydropyranyloxy-1-octyne (Example 154) successively with 233 mg. of 0.43M disiamylborane in diglyme, 22.5 g. of trimethylamine oxide, 150 ml. of 1N sodium hydroxide, 25.4 g. of iodine, and 900 ml. of 3:1:1 tetrahydrofuran-acetic acid-water as described in Example 151 gives the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04236027 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-659265b1752e4f169bc2cc6c9755395b |
| 출처 메모 | uspto-grants-1980_11 |