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Potassium Carbonate → 5-n-Heptyl-2-[2,3-difluoro-4-(2-fluorooctyloxy)phenyl]pyrimidine

HRID 2253721
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HRID 2253721 반응식
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([F:21])[C:15]=2[F:22])=[N:12][CH:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].C([O-])([O-])=O.[K+].[K+].S(C1C=CC(C)=CC=1)(O[CH2:33][CH:34]([F:41])[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])(=O)=O>C(C(C)=O)C>[CH2:1]([C:8]1[CH:13]=[N:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:33][CH:34]([F:41])[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[C:16]([F:21])[C:15]=2[F:22])=[N:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 142977062-Fluorooctyl p-toluenesulfonateHCID 1357870105-Heptyl-2-(2,3-difluoro-4-hydroxyphenyl)pyrimidine

생성물 1

HCID 200874145-n-Heptyl-2-[2,3-difluoro-4-(2-fluorooctyloxy)phenyl]pyrimidine

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

0.08 mol of 5-heptyl-2-(2,3-difluoro-4-hydroxyphenyl)pyrimidine, together with 11.6 g of K2CO3 and 25.6 g of optically active 2-fluoro-1-octyl tosylate in 70 ml of methyl ethyl ketone, are refluxed for 12 hours under a protective gas atmosphere. The reaction mixture is then hydolysed [sic], and the product is then worked up in a customary manner and purified by chromatography, to give optically active 5-n-heptyl-2-[2,3-difluoro-4-(2-fluorooctyloxy)phenyl]pyrimidine of melting point 56° C.

후처리

  1. custompurified by chromatography

출처 및 근거

ORD 기록
ord-a22054eb94364785900dfe44544729b2
출처 데이터셋
uspto-grants-1993_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05232624

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