홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Ethanol → 2beta-Ethoxy-3alpha-hydroxy-5alpha-pregnan-20-one

HRID 2253823
노트
인쇄 미리보기

반응식

HRID 2253823 반응식
[O:1]1[C@H:3]2[CH2:4][C@H:5]3[C@:20]([CH3:22])([CH2:21][C@@H:2]12)[C@@H:19]1[C@H:8]([C@H:9]2[C@:16]([CH3:23])([CH2:17][CH2:18]1)[C@@H:12]([C:13](=[O:15])[CH3:14])[CH2:11][CH2:10]2)[CH2:7][CH2:6]3.C(=O)(O)[O-].[Na+].[CH2:29]([OH:31])[CH3:30]>S(=O)(=O)(O)O>[CH2:29]([O:31][C@H:2]1[CH2:21][C@@:20]2([CH3:22])[C@@H:5]([CH2:6][CH2:7][C@@H:8]3[C@@H:19]2[CH2:18][CH2:17][C@@:16]2([CH3:23])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[C:13](=[O:15])[CH3:14])[CH2:4][C@@H:3]1[OH:1])[CH3:30]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 702Ethanol2회HCID 516892Sodium BicarbonateHCID 543466312alpha,3alpha-Epoxy-5alpha-pregnan-20-one

생성물 1

HCID 694636542beta-Ethoxy-3alpha-hydroxy-5alpha-pregnan-20-one수율 40%

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

실험 절차

2α,3α-Epoxy-5α-pregnan-20-one (180 mg) was dissolved in 20 mL of absolute ethanol and cooled to °C. and added to a cold 1.0 mL ethanol solution containing 3-drops of concentrated sulfuric acid. This reaction mixture was stirred for 30 minutes at this temperature and an additional 30 minutes at room temperature, poured into 20% sodium bicarbonate solution and washed several times with chloroform. The combined organic phase was dried over potassium carbonate and concentrated and purified by preparative TLC silica plate in hexane/ethyl acetate (1:1), to give (80 mg, 40% yield) the title compound as fine white crystals.

후처리

  1. temperaturecooled to °C
  2. washwashed several times with chloroform
  3. dry with materialThe combined organic phase was dried over potassium carbonate
  4. concentrationconcentrated
  5. custompurified by preparative TLC silica plate in hexane/ethyl acetate (1:1)

출처 및 근거

ORD 기록
ord-ceb2d61963d64de5a0c2b5ec259123bf
출처 데이터셋
uspto-grants-1993_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05232917

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트