(R)-2,2-diphenyl-2-(1-tosylpyrrolidin-3-yl)acetonitrile → (R)-2,2-diphenyl-2-(pyrrolidin-3-yl)acetonitrile
반응식
[C:1]([C:3]([C@H:16]1[CH2:20][CH2:19][N:18](S(C2C=CC(C)=CC=2)(=O)=O)[CH2:17]1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)#[N:2]>C(Cl)Cl>[C:1]([C:3]([C@H:16]1[CH2:20][CH2:19][NH:18][CH2:17]1)([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)#[N:2]참가 물질
3
실험 절차
A similar procedure starting with 3-(R)-(-)-(1-cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine (19.5 g-see Preparation 6(C)), gave 3-(R)-(-)-(1-cyano-1,1-diphenylmethyl)pyrrolidine, yield 9.5 g, [α]D25 -9.8° (c 1.0, CH2Cl2).
출처 및 근거
- ORD 기록
- ord-421808a8ff814fe2968fa0f76072af0b
- 출처 데이터셋
- uspto-grants-1993_08
- 특허 번호
- US05233053
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