HCID 67798252, 화합물 → HCID 67798074, 화합물

HRID 2254165노트

반응식

HRID 2254165 반응식
[CH2:1]([O:3][C:4]1([C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([OH:18])[CH:12]=2)[CH2:9][CH2:8][O:7][CH:6]([CH3:10])[CH2:5]1)[CH3:2]>C(O)C.[Pd]>[CH2:4]([O:18][C:13]1[CH:12]=[C:11]([C:4]2([O:3][CH2:1][CH3:2])[CH2:9][CH2:8][O:7][CH:6]([CH3:10])[CH2:5]2)[CH:16]=[C:15]([F:17])[CH:14]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 1

HCID 67798252HCID 67798252, 화합물

생성물 1

HCID 67798074HCID 67798074, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The (2SR,4SR)-4-ethoxy-4-(5-fluoro-3-hydroxyphenyl)-2-methyltetrahydropyran, used as a starting material, was obtained by hydrogenolysis of a solution of (2SR,4SR)-4-(3-benzyloxy-5-fluorophenyl)-4-ethoxy-2-methyltetrahydropyran (2.6 g, described in Note i. below Table X in Example 45) in ethanol (25 ml) in the presence of 10% palladium-on-charcoal catalyst (0.26 g ). The mixture was filtered and the filtrate was evaporated. There was thus obtained the required starting material (1.69 g, 89%), as an oil.

출처 및 근거

ORD 기록
ord-b40f65e1eec545ddbac351cef4e21c15
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05234950

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