Methyl L-phenylalaninate hydrochloride → HCID 54139201, 화합물
반응식
Cl.C[O:3][C:4](=[O:14])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[NH2:6].[CH2:15]([C:19]1[N:20]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[Cl:41])[C:21]([CH2:30][C:31](O)=[O:32])=[C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:23]=1)[CH2:16][CH2:17][CH3:18].ClC1C=CC=CC=1CN1C(C(O)=O)=CN=C1SCCC>>[CH2:15]([C:19]1[N:20]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[Cl:41])[C:21]([CH2:30][C:31]([NH:6][C@H:5]([C:4]([OH:3])=[O:14])[CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:32])=[C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:23]=1)[CH2:16][CH2:17][CH3:18]참가 물질
4
실험 절차
The title compound is prepared following the procedure of Example 1-(iii-iv) using phenylalanine methyl ester hydrochloride in place of glycine methyl ester hydrochloride and using 2-[n-butyl-1-(2-chlorophenyl)methyl-4-phenyl-1H-imidazol-5-yl]acetic acid (prepared as in U.S. Pat. No. 4,340,598) in place of 1-(2-chlorophenyl)methyl-2-propylthio-1H-imidazole-5 carboxylic acid.
후처리
- customprepared as in U.S