Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2254296생성일: 2026년 10월 27일
Trifluoromethanesulfonic anhydride → 5-Acetoxymethyl-1-[2-(1-adamantyl)ethyl]2-n-butylimidazole
https://huagongshe.com/reaction/2254296
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Trifluoromethanesulfonic anhydride | HCID 67749 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-(Tricyclo(3.3.1.1'3,7)dec-1-yl)ethanol | HCID 110810 | — |
| 반응물 | 1-Acetyl-2-n-butyl 5-acetoxymethyl imidazole | HCID 19793547 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Chloroform methanol | HCID 21584188 | — |
| 생성물 | 5-Acetoxymethyl-1-[2-(1-adamantyl)ethyl]2-n-butylimidazole | HCID 19936797 | — |
반응 단계
A mixture of 2-(1-adamantyl)ethanol and diisopropylethylamine in methylene chloride is added to triflic anhydride in methylene chloride at -78° C. under argon. After stirring the mixture at -78° C. for 45 minutes, 1-acetyl-2-n-butyl 5 (acetoxymethyl)imidazole in methylene chloride is added and the mixture is allowed to stand at room temperature for 4 days, then concentrated and heated on a steam bath with 10% sodium hydroxide, diluted with water, extracted with methylene chloride, dried, filtered and concentrated to give an oil. Chromatography (silica gel) in methanol chloroform gives 5-acetoxymethyl-1-[2-(1-adamantyl)ethyl]2-n-butylimidazole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05234917 |
|---|
| 출처 데이터셋 | uspto-grants-1993_08 |
|---|
| ORD ID | ord-ce54db51a3b3462ca9c6a80828cdfc86 |
|---|
| 출처 메모 | uspto-grants-1993_08 |
|---|
